'Accident-prone' Brit father-of-three, 71, was electrocuted by live wire while trying to get the 'perfect photograph' of the Himalayas on dream visit to India, inquest hears.Albanian illegal immigrants caught trying to burgle £1.5m home in Cheshire's wealthy 'footballer belt' will be jailed then kicked out of Britain after telling police: 'We're glad we got caught, it's too cold to stay here'.Bomb threats spark evacuation at six French airports and Molotov cocktail is hurled at Berlin synagogue with Europe on red alert after wave of deadly terror attacks.Police hunt for man in his work hi-vis who was caught scrawling 'coloniser' onto posters of innocent children kidnapped by Hamas - as figures show sevenfold increase in anti-Semitic incidents since Hamas attacks.Israel Palestine news LIVE: Joe Biden tells Netanyahu that Gaza hospital blast appears to be done 'by the other team, not you' and says Hamas has brought 'only suffering' to Palestinians.'When you cite the Nazis, you've lost the argument': Minister Grant Shapps slams veteran BBC correspondent John Simpson over his attempt to explain why the broadcaster won't call Hamas 'terrorists'.Moment terrified German officials lie face-down on tarmac at Tel Aviv airport as air raid sirens sound.'My prayers were answered': Mother of devout Sikh with '£2m life insurance' who was murdered in India by his British wife and her secret lover says she is 'relieved' after her son's killer was sentenced to death.Book into a winner: The results for Britain's best best hotels and B&Bs for 2024 are in!.Prince Harry and William's old polo club chairman is locked in High Court battle with fashion power couple neighbours: City tailor and Shein boss in legal fight over sunroom at their £2m home.No hard feelings! Princess Eugenie and Princess Beatrice are joined by Prince Harry's estranged pal Natalie Pinkham for dinner at swanky London restaurant.Transgender butcher who kidnapped and sexually abused schoolgirl after luring her into his car during horrific 27-hour ordeal is jailed for 20 years.Coleen Rooney fumes she might not get £1.8M legal bill back after Rebekah Vardy dragged her into 'pathetic' court case and won't forgive her WAG rival until she admits wrongdoing.Bale of straw is hung from London's Millennium Bridge as it undergoes urgent repairs because of ancient by-law requiring workers to warn river traffic below.Biden flies into Middle East tinderbox: President tells Israel's PM Netanyahu hospital bloodbath 'appears to have been done by the other team' as he lands in Tel Aviv with Gaza 'spiralling out of control'.'The smell of the dead is everywhere' Horrifying videos show 'sea of bodies' outside Gaza hospital and chaotic scenes during 'hell fire' that ripped through wards after devastating blast that killed hundreds.'It's from us? It looks like it!': Israel releases 'audio of Hamas operatives discussing failed rocket launch' and video showing missile exploding in the sky moments before blast killed hundreds at Gaza hospital.New pathways of implant debris-induced inflammatory reactions continue to be discovered, such as the "danger signaling" inflammasome pathway, which provides new targets for pharmaceutical intervention and improved implant performance. Some people are more predisposed to implant debris induced inflammation and metal "allergy" testing services are becoming available. ![]() Not only does activation of local (and systemic) inflammation result in decreased osteoblast function but osteoclast activity increases. However, both soluble and particulate debris derived from Co-Cr-Mo alloy implants can induce monocyte/macrophage activation and secretion of pro-inflammatory cytokines such as IL-1beta, TNFalpha, IL-6 and IL-8 via up-regulation of transcription factor NFkappabeta, and activation of inflammasome danger signaling in human macrophages. Generally, to produce an in vitro inflammatory response, particles need to be less than 10 mum, i.e. ![]() Elongated particles (fbers) are generally more pro-inflammatory than round particles, and there is a growing consensus that metals particles are more proinflammatory than polymers in vivo. Immune reactivity has been shown to depend on the number of particles produced or the dose (i.e., the concentration of phagocytosable particles per tissue volume, which can be characterized by knowing the size distribution and amount of debris). The response to implant debris is dominated by local immune activation, e.g. Eventual implant loosening due to aseptic osteolysis has been attributed to local inflammatory responses to wear and corrosion products that are produced by articulating implant interfaces. Biologic response to orthopedic implants debris is central to clinical performance.
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